Best of? I can't really say a best of for 2012. It was a great year for music. Especially as it wound down. That being said this Frank Turner tune I caught from another DJ (Props to Windsor here) is one I haven't been able to top listening to.
It has awesome energy, music, and lyrics. The lyrics I think are brilliant because while they have a defined meaning so to speak they have several spots that are ambiguous enough to have RL meaning / application at least to me. Thus I would have to say this tune touched on me the most out of anything from 2012 I listened to.